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Microtubule dynamics during
cell division.
 To
secure the equal transmission of cellular and genetic materials to each daughter
cell, acto-myosin contractions have to be precisely coordinated in space and
time with chromosome segregation. In order to achieve this coordination, a
crosstalk between spindle MTs and the actin cortex regulates cell division.
Pioneering work by Rappaport established that astral microtubules emanating from
each centrosomes and contacting the cortex direct formation of the cytokinesis
furrow at the equator of the anaphase cell only. A key unresolved question is to
understand how spindle microtubules functionally interact with cortical
acto-myosin contractions during cell division. We obtained evidences that ERM
proteins regulate astral microtubule
dynamics. Combining proteomics and
cell biology approaches we are currently investigating the molecular mechanism
by which actin binding proteins could regulate microtubule dynamics. |
