Seb Carreno Lab

Cell Biology of Cell Division

From Fly to Human : An integrated approach to understand how Actin and Microtubules interact during cell division.

Drosophila S2 cells labelled for Actin (red), Microtubules (green) and DNA (blue)

Cell division involves a stereotyped sequence of changes in cell morphology that are regulated by localized acto-myosin contractions of the cortex. In a coordinated manner microtubules of the mitotic spindle segregate the two sets of chromosomes. It is well established that the mitotic spindle specifies location of the contractile ring underlying the cleavage furrow. However the molecular mechanisms acting at the interface of Microtubules and Actin remain largely unknown. In our lab we are combining various experimental approaches (Cell biologics, Functional genomics, Proteomics and any other useful ics approaches) in different models (Drosophila & Mammalian cell lines) to understand the crosstalk between Actin and Microtubules.

 

INTRODUCTION

 ERMs & Cell division

P-inositides & Cell division

MT dynamics during cell division